I do cancer genomics and study tumor evolution, genomic instability, and phenotype plasticity to advance precision medicine.

I'm a postdoc in the Cancer Genomics and Evolution Laboratory at the University of Texas MD Anderson Cancer Center. I hold an NRSA fellowship from the National Cancer Institute and a TRIUMPH fellowship from the Cancer Prevention and Research Institute of Texas.

I earned my Ph.D. in Cell and Molecular Pathology at the University of Wisconsin - Madison where I developed novel methods to quantify chromosomal instability in tumors. Before that, I earned my B.Sc. in Biochemistry and Molecular Biology at the University of Wisconsin - Eau Claire.

bluesky · github · linkedin · orcid

The History of Chromosomal Instability in Genome-Doubled Tumors - Baker et al. Cancer Discovery. 2024. · A survey of chromosomal instability measures across mechanistic models - Lynch et al. PNAS. 2024. · The reckoning of chromosomal instability: past, present, future - Lynch et al. Chromosome Research. 2024. · Diverse microtubule-targeted anticancer agents kill cells by inducing chromosome missegregation on multipolar spindles - Zhou et al. PLOS Biology. 2023. · Quantifying chromosomal instability from intratumoral karyotype diversity using agent-based modeling and Bayesian inference - Lynch et al. eLife. 2022. · Short Proline-Substituted Muc1 Mucin Peptides Can Bind To Mouse Muc1 Monoclonal Antibody as Revealed by STD NMR - Yang et al. Journal of Undergraduate Chemistry Research. 2015. [ + ]

CINFER: scDNAseq-based estimates of chromosome mis-segregation rates. · ggsuperviolin: Violin SuperPlots for ggplot2 [ + ]